祁婧.胶质瘤中的表观遗传学:一场基因革命[J].,2018,5(5):1-7.
胶质瘤中的表观遗传学:一场基因革命
Epigenetics in glioma: a genetic revolution
投稿时间:2017-05-03  最后修改时间:2017-05-18
DOI:10.12095/j.issn.2095-6894.2018.05.001
中文关键词:  胶质瘤,表观遗传学,甲基化,靶点
英文关键词:glioma, epigenetics, methylation, target
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作者单位E-mail
祁婧 唐都医院 qj15034774786@163.com 
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中文摘要:
      一直以来异常的表观遗传学现象以及其在基因组和肿瘤进程、预后中的角色都是癌症研究的新兴领域之一. 在人类最 常见的原发性脑瘤胶质瘤中,特别是高度恶性的胶质母细胞瘤,异常的DNA 甲基化、组蛋白甲基化以及mRNA 表达都会从根本 上颠覆我们对于异质性肿瘤的认识。本文针对胶质瘤表观遗传学在胶质瘤诊断和预后中的价值进行探讨,为理解胶质瘤发生发 展的分子机制以及寻找新的更有效的药物靶点提供理论基础。
英文摘要:
      【Abstract】The ever?changing epigenetic phenomenon and its role in the process of genome and tumor progression are one of the emerging   areas of cancer research. In humans, the most common primary brain tumor gliomas, especially the most malignant glioblastoma, abnormal   DNA methylation, histone methylation and mRNA expression will fundamentally subvert our heterogeneous understanding of tumor. In this   paper, the value of glioma epigenetics in the diagnosis and prognosis of glioma is discussed, which provides a theoretical basis for under?   standing the molecular mechanism of glioma development and finding new and more effective drug targets.
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