任旭,王沂峰,孙利华.雷帕霉素对EMs血管生成影响的实验研究[J].,2018,5(5):16-20.
雷帕霉素对EMs血管生成影响的实验研究
Experimental study on the effect of rapamycin on the angiogenesis of EMsRen Xu1,Wang Yifeng2,Sun Lihua1
投稿时间:2018-03-20  最后修改时间:2018-05-04
DOI:10.12095/j.issn.2095-6894.2018.05.004
中文关键词:  EMs;血管生成;雷帕霉素;SCID 小鼠;MVD
英文关键词:endometriosis; antiangiogenesis; RAPA; SCID mice; MVD
基金项目:广州市医药卫生科技项目(2013A011030016)广东省科技计划项目(20140212)
作者单位E-mail
任旭 南方医科大学南海医院 nfykd@126.com 
王沂峰 南方医科大学珠江医院  
孙利华 南方医科大学南海医院  
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中文摘要:
      目的:探讨雷帕霉素对子宫内膜异位病灶生长及血管生成的影响,为子宫内膜异位症(EMs)的治疗探索新的方法。   方法:建立内异症SCID 小鼠动物模型,随机分为对照组10 例(生理盐水组)和治疗组10 例(雷帕霉素治疗组)。观察病灶的生   长情况,免疫组化法测定病灶组织微血管密度(MVD)的表达。结果:治疗组与对照组相比,异位病灶显著缩小(P<0.05);治疗组   的MVD 与对照组相比有显著性差异(P<0.05)。结论:雷帕霉素可显著抑制SCID 小鼠异位病灶的血管生成及异位病灶的生长,   是一种新型有效的治疗方法,为临床治疗EMs 提供理论依据。
英文摘要:
      【Abstract】Objective: To investigate the effect of rapamycin(RAPA)on the growth and angiogenesis of endometriosis, and explore a   new method for the treatment of endometriosis. Methods: the SCID mice model of endometriosis was established and divided into 10 cases   of control group (normal saline group) and 10 cases of treatment group (rapamycin treatment group). The growth of the lesion was   observed and the expression of microvascular density (MVD) in the lesion was measured by immunohistochemistry. Results: compared   with the control group, the ectopic focus was significantly reduced (P<0.05), and the MVD in the treatment group was significantly   different from that in the control group (P<0.05). Conclusion: rapamycin can significantly inhibit angiogenesis and ectopic growth of   ectopic lesions in SCID mice, and is an effective treatment for clinical treatment.
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