-indent: 21pt; font-size: 12px;">MicroRNAsmiRNA)是一类非编码RNA,研究表明,胶质瘤中miRNA表达水平异常与其发病机制及恶化密切相关,这为研究肿瘤发病机理提供了新的方向,同时为癌症的诊断与治疗提供新的策略。神经胶质瘤是颅内最频发的恶性肿瘤,根据其恶性程度,世界卫生组织(WHO)将其分为5个等级,I-IV,每个等级中又分为许多亚型。通过抑制参与调控胶质瘤细胞增殖和凋亡相关基因的表达,miRNA参与胶质瘤发生发展的调控,影响预后。此外,miRNA还影响着胶质瘤的放、化疗抵抗,它不仅可以作为胶质瘤临床诊断与治疗的新的分子靶标,还可以作为胶质瘤基因治疗的靶点。本文综述了目前在神经胶质瘤中发现的表达水平上调或下调的miRNAs,及其在胶质瘤发生发展中的生物学功能,讨论了miRNAs在神经胶质瘤临床治疗中的诊断与治疗潜力。

Systematic Review of MicroRNAs and its Therapeutic Potential in Glioma
Nan Liu1, Yanyang Tu2
1Department of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi,
China;
2Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
   MicroRNAs (miRNAs) are short noncoding RNAs. The discovery of miRNA has provided a novel tool to the research of tumor pathogenesis, and a new strategy to the diagnosis and prognosis of human cancers. Currently, numerous studies have indicated that the deregulation of miRNAs in glioma is closely related to glioma pathogenesis and progress. miRNAs function as key regulators of glioma through negative control of the target gene expression, by targeting the 3’?untranslated region of its messenger RNA which regulate the
cell proliferation, apoptosis and prognosis of glioma. Moreover, radiation and chemotherapy resistance in glioma therapy is also caused by deregulation of miRNAs. It has been suggested that miRNAs act as tumor suppressors or oncogenes in glioma. Not only can miRNAs be used as biomarkers of glioma diagnosis and therapy, but also as novel targets of glioma gene therapy.
Key words: Glioma, microRNAs, molecular therapy