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流行病学数据显示,近些年来,前列腺癌的发病率逐年上升,已经成为威胁成年男性的一项重大疾病。因此,对前列腺疾病的研究与治疗显得尤为重要。

本文选取中国人民解放军第150中心医院的187例前列腺患者进行研究,探讨前列腺患者前列腺特异性抗原的相关变量(TPSA;FPSA;PSAD;F/TPSA)与风险因素的相关性。结果显示,TPSAFPSA与前列腺癌的风险因素呈正相关,而F/TPSA与前列腺癌的风险因素无相关性。因此,PSAD,FPSA以及PSA的相关变量可能会主导前列腺癌的治疗。这一研究不仅有助于更好地了解基础生物学,而且为后期前列腺的治疗提供了有效的引导。

 

Analysis of the Correlation between the Related Variables of Prostate-specific Antigen and Risk Factors of Prostate Carcinoma

Daoyuan Wang, Tiejun Yang, Yongqiang Zou

 

Aim: To investigate the correlation between the related variables of prostate-specific antigen (PSA) and risk factors in patients with prostate carcinoma.

Methods: The clinical records of 187 cases with prostate carcinoma, diagnosed by biopsy, were retrospectively analyzed to assess the correlation of PSA density (PSAD), free PSA (FPSA), and FPSA/total PSA (TPSA) with risk factors in prostate carcinoma.

Results: The results from “Spearman rank correlation analysis” and “rank sum test” revealed that TPSA and FPSA were positively correlated with risk factors for prostate cancer patients, whereas there was no correlation between F/TPSA and risk factors.

Conclusion: PSAD, FPSA, and the related variables of PSA may serve as valuable tools to guide the treatment of prostate cancer.

 

Key words: Free/total prostate-specific antigen, prostate cancer, prostate-specific antigen, prostate-specific antigen density

 

DOI:10.4103/2395-3977.159524

(From Cancer Translational Medicine)

 

原文链接:http://www.cancertm.com/article.asp?issn=2395-3977;year=2015;volume=1;issue=3;spage=77;epage=79;aulast=Wang